Tip 5: Punctuation can enhance your search as well. Use quotes ("search term") to only include pages with the same words in the same order. But only use this if you are looking for an exact word or phrase, otherwise you may exclude helpful results. Add an asterisk (search term*) as a placeholder for any unknown or wildcard terms. For example, C*l Tunnel would give you results for Cubital Tunnel and Carpal Tunnel. Place a question mark (search term?) for single-character wildcard matching. For example, pa?ent would give you results for parent, patent, etc. You may also use the plus sign (search + word) between words for words you must have in the results.
We included 12 studies with altogether 671 participants. Two high quality randomized controlled trials with altogether 141 participants demonstrated clinical improvement of carpal tunnel syndrome at one month or less following local corticosteroid compared to placebo injection ( relative risk (95% confidence intervals to )). One trial compared local corticosteroid injection to oral corticosteroid and at 12 weeks after treatment there was significantly more improvement in the injection group ( mean difference - (95% confidence intervals - to -)). In one trial , the rate of improvement after one month was greater after local than systemic corticosteroid injection ( relative risk (95% confidence intervals to )). In one trial , symptoms did not improve significantly more in the injection group at eight weeks after injection compared to treatment with anti-inflammatory medication and splinting ( mean difference (95% confidence intervals - to )). Two injections versus one injection of local corticosteroid did not provide further clinical improvement, mean difference - (95% CI - to ).