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Northrup: In the late 1980s, research began to suggest that CEE and other estrogens such as 17-beta estradiol (., Estrace, Vivelle dot, Climara) raised the levels of the so-called “good cholesterol” HDL in the blood. It was posited that this increase in HDL would likely prevent heart disease in millions of women. And since heart disease is the number one killer of women, it suddenly became standard practice to prescribe what was called hormone replacement therapy (HRT) to all women during perimenopause as the sine qua non of cardiovascular health! If a woman questioned this, she was sometimes dismissed from her doctor’s practice—that is how strong the belief in HRT was back then.