Neurosteroid effects in the central nervous system

Sripada et al. reported that oral pregnenolone is preferentially metabolized into the neurosteroid allopregnanolone rather than into other steroids such as DHEA or cortisol . [19] In further research by their group, a single 400 mg dose of oral pregnenolone at 3 hours post-administration was found to result in a 3-fold elevation in serum levels of pregnenolone and a 7-fold increase in allopregnanolone levels. [19] Pregnanolone levels increased by approximately 60% while DHEA levels decreased non-significantly by approximately 5% and cortisol levels were not affected. [19] Another study found that allopregnanolone levels were increased by 3-fold at 2 hours post-administration following a single 400 mg oral dose of pregnenolone. [19]

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Intraocular pressure, glaucoma
Have you heard of DHEA causing high IOP (intraocular pressure) or possibly temporary glaucoma. I have been taking DHEA for about a year. I like the benefits it has provided both physically and mentally. However my last flight physical for the military showed me having high IOP in both eyes. Two days after I stopped taking DHEA my pressures where back to normal.
   I have not heard of this side effect yet, and I have not seen it mentioned in the medical literature, however it is a possibility to consider. There's a lot we don't know about the long term effects of DHEA. If your IOP is increased again after restarting the DHEA and then returns to normal after stopping, then that would make it quite likely that in your case it was involved.

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Neurosteroid effects in the central nervous system

neurosteroid effects in the central nervous system

Our optimized screening platform and our unique bioinformatics tools allow our passionate scientists to provide you with a comprehensive offer and share with you Hybrigenics expertise to boost your research project. You can trust us. With more than 1800 academic & industrial researchers using our services from over 35 countries, Hybrigenics Services is internationally recognized as a protein interactions expert. Our results have been quoted in more than 400 scientific publications so far. You can check our customers' testimonials or watch our videos to learn how we run a protein interactions project.

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